Ravindran J S, Owen P, Lagan A, Lewis J, Korendowych E, Welsh K, McHugh N
Royal National Hospital for Rheumatic Diseases, Bath, UK.
Rheumatology (Oxford). 2004 Jan;43(1):22-6. doi: 10.1093/rheumatology/keg443. Epub 2003 Jul 30.
To investigate polymorphisms of interleukin (IL) 1alpha, IL-1beta and IL-1 receptor R1 genes in patients with psoriatic arthritis (PsA), their relationship to the age of onset of psoriasis and the pattern of joint involvement.
One hundred and forty well-characterized patients with PsA were studied. One hundred healthy controls were recruited from primary care. All were genotyped for single-nucleotide polymorphisms in the genes for IL-1alpha (position -889), IL-1beta (position +3953) and IL-1R1 (position +970). The frequencies of the respective variants were compared between patients and controls and in relation to age of onset of psoriasis, to clinical subsets of the disease and to the presence of erosions.
All three polymorphisms were in Hardy-Weinberg equilibrium in both patients and controls. The frequency of IL-1alpha -889 CC homozygotes was significantly increased in PsA patients compared with normal controls [58 vs 40%, odds ratio (OR) 2.06, 95%, confidence interval (CI) 1.22-3.47]. The frequency of the IL-1alpha -889 C allele was significantly increased in PsA patients compared with controls (75 vs 65%, OR 1.65, 95% CI 1.11-2.45). In subset analysis there were no other significant differences in allelic frequencies for the IL-1alpha -889 C/T, IL-1beta +3953 C/T and IL-1R1 +970 C/T polymorphisms.
The IL-1 gene complex may play a role in the development of PsA and/or psoriasis or act as a marker for other genes on chromosome 2q12 to 2q13.
研究银屑病关节炎（PsA）患者白细胞介素（IL）-1α、IL-1β和IL-1受体R1基因的多态性，以及它们与银屑病发病年龄和关节受累模式的关系。
对140例特征明确的PsA患者进行研究。从初级保健机构招募100名健康对照。对所有研究对象进行IL-1α基因（-889位点）、IL-1β基因（+3953位点）和IL-1R1基因（+970位点）单核苷酸多态性的基因分型。比较患者和对照之间以及与银屑病发病年龄、疾病临床亚组和侵蚀存在情况相关的各自变异体的频率。
患者和对照中所有三种多态性均处于哈迪-温伯格平衡。与正常对照相比，PsA患者中IL-1α -889 CC纯合子的频率显著增加[58%对40%，优势比（OR）2.06，95%置信区间（CI）1.22 - 3.47]。与对照相比，PsA患者中IL-
