呼气末正压调节全氟化合物从肺中的蒸发。

Positive end-expiratory pressure modulates perfluorochemical evaporation from the lungs.

作者信息

Trevisanuto D, Jeng M J, Weis C M, Fox W W, Wolfson M R, Shaffer T H

机构信息

Department of Pediatrics, Padua University, Padua, Italy.

出版信息

Biol Neonate. 2003;84(1):53-8. doi: 10.1159/000071444.

DOI:10.1159/000071444

PMID:12890937

Abstract

To study the effects of positive end-expiratory pressure (PEEP) level on perfluorochemical (PFC) elimination profiles (E(L)), 6 ml/kg of perflubron were instilled into healthy anesthetized rabbits. The ventilation strategy was to maintain constant minute ventilation (300 ml/kg/min) and mean airway pressure (7-8 cm H(2)O) while randomly changing the PEEP levels from 5 to 0, 1, 3, and 10 cm H(2)O, each for a period of 15 min. The PFC content in the expired gas was measured and the E(L) was calculated. There was a significant reduction in the E(L) when decreasing the PEEP levels from 5 to 0 cm H(2)O, but no differences were seen when the PEEP was increased from 5 to 10 cm H(2)O. The results indicate that PEEP levels influence PFC elimination profiles; therefore, the measurement of the E(L) and PEEP levels should be considered when optimizing supplemental PFCs during partial liquid ventilation.

摘要

为研究呼气末正压（PEEP）水平对全氟化合物（PFC）清除曲线（E(L)）的影响，将6 ml/kg的全氟溴辛烷注入健康的麻醉兔体内。通气策略是维持恒定的分钟通气量（300 ml/kg/min）和平均气道压（7 - 8 cm H₂O），同时将PEEP水平从5随机改变为0、1、3和10 cm H₂O，每个水平持续15分钟。测量呼出气体中的PFC含量并计算E(L)。当PEEP水平从5降至0 cm H₂O时，E(L)显著降低，但当PEEP从5升至10 cm H₂O时未观察到差异。结果表明，PEEP水平影响PFC清除曲线；因此，在部分液体通气期间优化补充PFC时，应考虑测量E(L)和PEEP水平。