Schultz Christian, Tautz Juliane, Reiss Irwin, Möller Jens Christian
Department of Pediatrics, Medical University of Lübeck, Germany.
Biol Neonate. 2003;84(1):64-6. doi: 10.1159/000071446.
Lung inflammation plays an important role in the pathogenesis of chronic lung disease in preterm infants. To test the hypothesis that prolonged mechanical ventilation induces pulmonary inflammation, we analyzed pro- and anti-inflammatory mediators in bronchoalveolar lavage fluid obtained from ventilated preterm infants having respiratory distress syndrome. Our results show a strong correlation between the duration of mechanical ventilation and the amount of proinflammatory mediators. However, the anti-inflammatory cytokine interleukin 10 remained stable during the whole period of mechanical ventilation. These data support the hypothesis that prolonged mechanical ventilation contributes to the development of chronic lung disease by the induction of lung inflammation without adequate stimulation of the counterregulatory cytokine interleukin 10 in preterm infants with respiratory distress syndrome.
肺部炎症在早产儿慢性肺病的发病机制中起重要作用。为了验证长时间机械通气会诱发肺部炎症这一假说，我们分析了从患有呼吸窘迫综合征的机械通气早产儿获取的支气管肺泡灌洗液中的促炎和抗炎介质。我们的结果显示，机械通气时间与促炎介质的量之间存在很强的相关性。然而，抗炎细胞因子白细胞介素10在整个机械通气期间保持稳定。这些数据支持了这样一种假说，即长时间机械通气通过诱发肺部炎症，而在患有呼吸窘迫综合征的早产儿中没有充分刺激反调节细胞因子白细胞介素10，从而导致慢性肺病的发展。
