Chu M, Rehfeld J F, Borch K
Department of Surgery, University Hospital of Linköping, Sweden.
Digestion. 1992;53(1-2):28-34. doi: 10.1159/000200968.
The effects of gastric fundectomy and antrectomy on the colonic mucosa were studied in hamsters over 5 and 25 days. Sham-operated animals served as controls. Basal plasma gastrin concentrations were significantly increased after fundectomy and significantly decreased after antrectomy. Five days after fundectomy, there was a significant increase in scintigraphically determined colonic tissue [3H]-thymidine uptake and [3H]-thymidine labeling index of goblet cells, both of which were reduced 5 days after antrectomy. After fundectomy, the labeling index was maximal in differentiating-proliferative cells in the midportion of the colonic crypts, whereas the labeling index of the immature proliferative cells at the base of the crypts did not differ from that in the controls. On day 25, the crypt size and the number and percentage of goblet cells in the crypts were significantly increased in fundectomized animals. The number and percentage of goblet cells in antrectomized animals were significantly reduced on day 25. It is concluded that fundectomy in the hamster induces colonic mucosal hyperplasia with goblet cell proliferation, whereas antrectomy leads to retardation of colonic goblet cell proliferation.
在5天和25天的时间里，研究了胃底切除术和胃窦切除术对仓鼠结肠黏膜的影响。假手术动物作为对照。胃底切除术后基础血浆胃泌素浓度显著升高，胃窦切除术后显著降低。胃底切除术后5天，闪烁显像测定的结肠组织[3H]-胸腺嘧啶核苷摄取量和杯状细胞的[3H]-胸腺嘧啶核苷标记指数显著增加，而胃窦切除术后5天两者均降低。胃底切除术后，标记指数在结肠隐窝中部的分化增殖细胞中最高，而隐窝底部未成熟增殖细胞的标记指数与对照组无差异。在第25天，胃底切除动物的隐窝大小以及隐窝中杯状细胞的数量和百分比显著增加。胃窦切除动物在第25天杯状细胞的数量和百分比显著减少。结论是，仓鼠胃底切除术可诱导结肠黏膜增生并伴有杯状细胞增殖，而胃窦切除术则导致结肠杯状细胞增殖迟缓。
