Chu M, Rehfeld J F, Borch K
Department of Surgery, University Hospital of Linköping, Sweden.
Dig Dis Sci. 1993 Nov;38(11):1978-84. doi: 10.1007/BF01297072.
The effect of pancreaticobiliary diversion (PBD) on the colonic mucosa was studied in hamsters over 5, 10, and 24 days. Sham-operated animals served as controls. At all three time intervals, experimental animals had increased plasma cholecystokinin concentrations and decreased gastrin concentrations. Five days after PBD, there was an increase in scintigraphically measured [3H]thymidine incorporation into colonic tissue. Correspondingly, there was an increase in the [3H]thymidine DNA labeling index of goblet cells in the colonic mucosa. The total number of cells in the colonic crypt columns were significantly increased on days 5, 10 and 24. Whether this proliferative response in the colon is due to increased release of cholecystokinin, enteroglucagon, other aberrations of hormones or growth factors, or simply an increased bile load on the colonic mucosa remains to be clarified. Such further studies may reveal an alternative animal model for studies on risk factors in colonic carcinogenesis.
在仓鼠身上研究了胰胆分流术（PBD）对结肠黏膜的影响，时间跨度为5天、10天和24天。假手术动物作为对照。在所有这三个时间间隔，实验动物的血浆胆囊收缩素浓度升高，胃泌素浓度降低。PBD术后5天，闪烁扫描测量的结肠组织中[3H]胸腺嘧啶核苷掺入量增加。相应地，结肠黏膜杯状细胞的[3H]胸腺嘧啶核苷DNA标记指数增加。结肠隐窝柱中的细胞总数在第5天、第10天和第24天显著增加。结肠中的这种增殖反应是由于胆囊收缩素、肠高血糖素释放增加、激素或生长因子的其他异常，还是仅仅由于结肠黏膜上胆汁负荷增加，仍有待阐明。此类进一步研究可能会揭示一种用于研究结肠癌发生风险因素的替代动物模型。
