Michiels Carine
Laboratoire de Biochimie et Biologie cellulaire, University of Namur, Namur, Belgium.
J Cell Physiol. 2003 Sep;196(3):430-43. doi: 10.1002/jcp.10333.
Endothelial cells play a wide variety of critical roles in the control of vascular function. Indeed, since the early 1980s, the accumulating knowledge of the endothelial cell structure as well as of the functional properties of the endothelial cells shifted their role from a passive membrane or barrier to a complex tissue with complex functions adaptable to needs specific in time and location. Hence, it participates to all aspects of the vascular homeostasis but also to physiological or pathological processes like thrombosis, inflammation, or vascular wall remodeling. Some of the most important endothelial functions will be described in the following review and more specifically, their role in blood vessel formation, in coagulation and fibribolysis, in the regulation of vascular tone as well as their participation in inflammatory reactions and in tumor neoangiogenesis.
内皮细胞在血管功能控制中发挥着多种关键作用。事实上，自20世纪80年代初以来，对内皮细胞结构以及内皮细胞功能特性的认识不断积累，这使其作用从被动的膜或屏障转变为具有复杂功能的复杂组织，能够适应特定时间和位置的需求。因此，它参与血管稳态的各个方面，也参与血栓形成、炎症或血管壁重塑等生理或病理过程。以下综述将描述一些最重要的内皮功能，更具体地说，是它们在血管生成、凝血和纤维蛋白溶解、血管张力调节中的作用，以及它们在炎症反应和肿瘤新生血管形成中的参与情况。
