[西咪替丁肝炎]

[Cimetidine hepatitis].

作者信息

Zaidenstein R, Cohen N, Golik A

机构信息

Medical Dept. A, Assaf Harofeh Medical Center, Zerifin.

出版信息

Harefuah. 1992 Dec 15;123(12):516-8, 572.

PMID:1289197

Abstract

A 41-year-old man with rheumatoid arthritis developed severe acute hepatitis 3 days after starting cimetidine for duodenal ulcer. Other causes were ruled out and he recovered after cimetidine was discontinued. Mild transient elevations of hepatic enzymes have been reported in 3.6% of patients taking cimetidine. However, only 12 cases of severe acute hepatitis associated with cimetidine, mostly secondary to idiosyncrasy, have been reported in the English literature. This rare but serious complication of cimetidine should be kept in mind.

摘要

一名41岁的类风湿性关节炎患者在开始服用西咪替丁治疗十二指肠溃疡3天后出现严重急性肝炎。排除了其他病因，停用西咪替丁后患者康复。据报道，服用西咪替丁的患者中有3.6%出现轻度短暂性肝酶升高。然而，英文文献中仅报道了12例与西咪替丁相关的严重急性肝炎病例，大多继发于特异反应性。应牢记西咪替丁这种罕见但严重的并发症。