van de Griendt E J, Rietra P J, van Andel R N
Onze Lieve Vrouwe Gasthuis, afd. Kindergeneeskunde, Amsterdam.
Ned Tijdschr Geneeskd. 2003 Jul 12;147(28):1367-9.
In an 8.5-year-old boy with severe recurring unilateral swelling of the neck, infection with Mycobacterium haemophilum was established. In addition to the more usual causative agents, cervical lymphadenopathy in children can, in rare cases, be caused by M. haemophilum. The skin tests did not differentiate between Mycobacterium avium and Mycobacterium tuberculosis infection. There was no evidence of specific immune deficiencies. The swelling did not respond to treatment with four tuberculostatic drugs (rifampicin, isoniazid, pyrazinamide and ethambutole), nor to repeated surgical excision. Finally, M. haemophilum grew on the culture despite sub-optimal culture conditions. Thereupon the patient was treated with co-trimoxazole and recovered in two weeks. This is the first patient with cervical lymphadenopathy caused by M. haemophilum to be described in the Netherlands. M. haemophilum grows on an iron-rich medium at a relatively low temperature (30-32 degrees C). In cases of cervical lymphadenopathy, it is advisable to consider M. haemophilum as a cause and to adjust the culture conditions accordingly.
在一名8岁半患有严重复发性单侧颈部肿胀的男孩身上,确诊感染了嗜血性分枝杆菌。除了更常见的致病因素外,儿童颈部淋巴结病在罕见情况下可由嗜血性分枝杆菌引起。皮肤试验无法区分鸟分枝杆菌感染和结核分枝杆菌感染。没有特异性免疫缺陷的证据。肿胀对四种抗结核药物(利福平、异烟肼、吡嗪酰胺和乙胺丁醇)治疗无反应,对反复手术切除也无反应。最后,尽管培养条件不理想,嗜血性分枝杆菌仍在培养物中生长。于是该患者接受了复方新诺明治疗,两周后康复。这是荷兰首例描述的由嗜血性分枝杆菌引起的颈部淋巴结病患者。嗜血性分枝杆菌在富含铁的培养基上于相对较低温度(30 - 32摄氏度)下生长。对于颈部淋巴结病病例,建议考虑嗜血性分枝杆菌作为病因并相应调整培养条件。