Jensen B, Wittrup I H, Bliddal H, Danneskiold-Samsøe B, Faber J
Parker Institute, Frederiksberg Hospital, Copenhagen, Denmark.
Scand J Rheumatol. 2003;32(3):146-50. doi: 10.1080/03009740310002470.
To compare bone mass (BMD) in women with fibromyalgia (FM) with healthy females, and to evaluate whether self-reported pain and lack of functional capacity correlate to reduced BMD in FM patients.
Thirty-one FM patients (20 pre- and 11 postmenopausal) and fourty-one healthy women (30 pre- and 10 postmenopausal) were enrolled in the study. BMD of the lumbar spine and the femoral neck was measured by a DEXA (Norland) scanner. Self reported pain was measured on a Visual Analog Scale (VAS). The Activity of Daily Living (ADL) component of the Fibromyalgia Impact Questionnaire (FIQ-ADL) was used as measure for physical capacity.
BMD-lumbar spine and BMD-femoral neck did not differ significantly between FM patients and controls, though premenopausal FM patients tended to have lower BMD-femoral neck (p = 0.09). Self reported pain and FIQ-ADL among FM patients correlated with BMD-femoral neck (r(s) = -0.52, p = 0.003); (r(s) = -0.31, p = 0.09).
Premenopausal FM patients tended to have lower BMD of hip than controls. Self reported pain correlated negatively to BMD. Thus, the severity of FM might have a negative impact on bone mass.
比较纤维肌痛（FM）女性与健康女性的骨量（BMD），并评估自我报告的疼痛和功能能力缺失是否与FM患者骨量降低相关。
本研究纳入了31例FM患者（20例绝经前和11例绝经后）和41例健康女性（30例绝经前和10例绝经后）。采用双能X线吸收仪（Norland）扫描仪测量腰椎和股骨颈的骨密度。自我报告的疼痛采用视觉模拟量表（VAS）进行测量。纤维肌痛影响问卷（FIQ-ADL）中的日常生活活动（ADL）部分用作身体能力的测量指标。
FM患者与对照组之间的腰椎骨密度和股骨颈骨密度无显著差异，尽管绝经前FM患者的股骨颈骨密度有降低趋势（p = 0.09）。FM患者的自我报告疼痛和FIQ-ADL与股骨颈骨密度相关（r(s) = -0.52，p = 0.003）；（r(s) = -0.31，p = 0.09）。
绝经前FM患者的髋部骨密度往往低于对照组。自我报告的疼痛与骨密度呈负相关。因此，FM的严重程度可能对骨量有负面影响。
