Ulusoy H, Sarica N, Arslan S, Ozyurt H, Cetin I, Birgul Ozer E, Yildirim N
Gaziosmanpasa University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Tokat, Turkey.
Bratisl Lek Listy. 2010;111(11):604-9.
To compare serum vitamin D levels and bone mineral density (BMD) values in patients with fibromyalgia and healthy controls.
The so far available reports of low levels of vitamin D and low BMD values in patients with fibromyalgia are inconsistent.
Serum 25-hydroxyvitamin D (25-OHD) levels and BMD values were measured in thirty women with fibromyalgia and compared with thirty age-matched healthy women. Serum calcium, phosphorus, alkaline phosphatase and parathyroid hormone (PTH) levels were also measured. All participants completed the Fibromyalgia Impact Questionnaire (FIQ) and Hospital Anxiety and Depression Score (HADS). Pain severity was assessed with visual analog scale (VAS).
Mean serum 25-OHD levels did not differ between the groups (fibromyalgia 10.57 +/- 10.46, controls 10.87 +/- 5.52 ng/l; p=0.89); nor did the frequency of vitamin D deficiency (25-OHD < or = 20 ng/l) in each group (fibromyalgia 86.7%, controls 96.7%; p=0.353). Although, mean serum PTH level was found significantly higher in fibromyalgic patients than in controls (p=0.014), only one patient and two of controls had barely elevated PTH levels. There was no relationship between vitamin D level and FIQ score (p=0.707) or HADS (p=0.824) or pain VAS (p=0.414). BMD values in the patients with fibromyalgia were comparable to those in controls at both, the lumbar spine (p=0.866) and femur neck (p=0.61).
Neither vitamin D levels nor BMD values are different between women with and without fibromyalgia. In this cross-sectional study, mean serum PTH level was found higher in the fibromyalgic patients than in controls. Nevertheless, in order to confirm the findings of this preliminary study it is still necessary to perform a controlled longitudinal study (Tab. 2, Fig. 2, Ref. 35). Full Text in free PDF www.bmj.sk.
比较纤维肌痛患者与健康对照者的血清维生素D水平和骨密度（BMD）值。
目前关于纤维肌痛患者维生素D水平低和骨密度值低的报道并不一致。
测量30名纤维肌痛女性患者的血清25-羟维生素D（25-OHD）水平和骨密度值，并与30名年龄匹配的健康女性进行比较。还测量了血清钙、磷、碱性磷酸酶和甲状旁腺激素（PTH）水平。所有参与者均完成了纤维肌痛影响问卷（FIQ）和医院焦虑抑郁量表（HADS）。采用视觉模拟量表（VAS）评估疼痛严重程度。
两组之间的平均血清25-OHD水平无差异（纤维肌痛组10.57±10.46，对照组10.87±5.52 ng/l；p = 0.89）；每组维生素D缺乏（25-OHD≤20 ng/l）的频率也无差异（纤维肌痛组86.7%，对照组96.7%；p = 0.353）。尽管发现纤维肌痛患者的平均血清PTH水平显著高于对照组（p = 0.014），但只有1例患者和2例对照者的PTH水平略有升高。维生素D水平与FIQ评分（p = 0.707）、HADS评分（p = 0.824）或疼痛VAS评分（p = 0.414）之间均无关联。纤维肌痛患者在腰椎（p = 0.866）和股骨颈（p = 0.61）的骨密度值与对照组相当。
有纤维肌痛和无纤维肌痛的女性之间，维生素D水平和骨密度值均无差异。在这项横断面研究中，发现纤维肌痛患者的平均血清PTH水平高于对照组。然而，为了证实这项初步研究的结果，仍有必要进行一项对照纵向研究（表2，图2，参考文献35）。全文免费PDF版见www.bmj.sk。
