Daminet Sylvie, Ferguson Duncan C
Department of Small Animal Medicine, Ghent University, Merelbeke, Belgium.
J Vet Intern Med. 2003 Jul-Aug;17(4):463-72. doi: 10.1111/j.1939-1676.2003.tb02467.x.
Several drugs can affect thyroid function test results in humans and eventually lead to an erroneous evaluation of thyroid function. These medications can alter the synthesis, secretion, transport, or metabolism of thyroid hormones. Some drugs also directly inhibit the hypothalamic-pituitary-thyroid axis. The effects of drugs on thyroid function in dogs have long been underestimated and have most likely contributed to the overdiagnosis of hypothyroidism in this species. This manuscript 1st reviews pertinent thyroid physiology followed by an overview of drugs for which the effects on canine thyroid function have been studied. The effects of glucocorticoids, propranolol, sulfonamides, phenobarbital, potassium bromide, and nonsteroidal anti-inflammatory agents (NSAIDs) on canine thyroid function are summarized here. Knowledge of the potential effect of these medications on thyroid function should contribute to a more reliable interpretation of thyroid function test results in dogs.
几种药物可影响人类的甲状腺功能测试结果，并最终导致对甲状腺功能的错误评估。这些药物可改变甲状腺激素的合成、分泌、运输或代谢。一些药物还直接抑制下丘脑 - 垂体 - 甲状腺轴。长期以来，药物对犬类甲状腺功能的影响一直被低估，很可能导致了该物种甲状腺功能减退的过度诊断。本手稿首先回顾相关的甲状腺生理学，然后概述已研究其对犬类甲状腺功能影响的药物。本文总结了糖皮质激素、普萘洛尔、磺胺类药物、苯巴比妥、溴化钾和非甾体抗炎药（NSAIDs）对犬类甲状腺功能的影响。了解这些药物对甲状腺功能的潜在影响，应有助于更可靠地解读犬类的甲状腺功能测试结果。
