Spiliotis Elias T, Nelson W James
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305-5435, USA.
Curr Opin Cell Biol. 2003 Aug;15(4):430-7. doi: 10.1016/s0955-0674(03)00074-7.
During many key biological processes, exocytosis is confined to distinct regions of the plasma membrane. Spatial control of exocytosis correlates with altered membrane skeleton dynamics and assembly of local membrane microdomains. These domains act as local stages for the assembly and the regulation of molecular complexes (targeting patches) that mediate vesicle-membrane fusion. Furthermore, local activation of signaling pathways reinforces formation of these patches and might effect global repositioning of the secretory pathway toward sites of localized exocytosis.
在许多关键的生物过程中,胞吐作用局限于质膜的特定区域。胞吐作用的空间控制与膜骨架动力学的改变以及局部膜微区的组装相关。这些微区充当了介导囊泡 - 膜融合的分子复合物(靶向斑)组装和调节的局部平台。此外,信号通路的局部激活增强了这些斑的形成,并可能影响分泌途径向局部胞吐作用位点的整体重新定位。