果蝇在体内将1,4 - 丁二醇代谢为γ-羟基丁酸。

Drosophila metabolize 1,4-butanediol into gamma-hydroxybutyric acid in vivo.

作者信息

Satta Rosalba, Dimitrijevic Nikola, Manev Hari

机构信息

Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA.

出版信息

Eur J Pharmacol. 2003 Jul 25;473(2-3):149-52. doi: 10.1016/s0014-2999(03)01993-9.

DOI:10.1016/s0014-2999(03)01993-9

PMID:12892832

Abstract

A solvent, 1,4-butanediol, is also abused as a recreational drug. In mammals, 1,4-butanediol is metabolized into gamma-hydroxybutyric acid (GHB), which stimulates metabotropic gamma-aminobutyric acid (GABA) GABAB and putative GHB receptors. Here we show that in vivo injection of 1,4-butanediol into adult Drosophila leads to GHB synthesis (GHB was detectable 5 min after 1,4-butanediol injection and increased dramatically 1-2 h later). This synthesis of GHB was accompanied by an impairment of locomotor activity that was mimicked by a direct injection of GHB into flies. We propose Drosophila as a model to study the molecular actions of 1,4-butanediol and GHB.

摘要

溶剂1,4 - 丁二醇也被滥用为消遣性毒品。在哺乳动物中，1,4 - 丁二醇会代谢为γ-羟基丁酸（GHB），后者会刺激代谢型γ-氨基丁酸（GABA）的GABAB受体以及假定的GHB受体。在此我们表明，向成年果蝇体内注射1,4 - 丁二醇会导致GHB的合成（注射1,4 - 丁二醇5分钟后可检测到GHB，1 - 2小时后显著增加）。GHB的这种合成伴随着运动活性的受损，直接向果蝇注射GHB也会出现类似情况。我们提出将果蝇作为研究1,4 - 丁二醇和GHB分子作用的模型。