精神分裂症中的神经学软体征和轻微身体异常：家庭内部的差异传递

Neurological soft-signs and minor physical anomalies in schizophrenia: differential transmission within families.

作者信息

Gourion David, Goldberger Céline, Bourdel Marie-Chantal, Bayle Frank Jean, Millet Bruno, Olie Jean-Pierre, Krebs Marie-Odile

机构信息

Service Hospitalo-Universitaire, Hôpital Sainte-Anne, 7 rue Cabanis, 75014 Paris, France.

出版信息

Schizophr Res. 2003 Sep 1;63(1-2):181-7. doi: 10.1016/s0920-9964(02)00333-x.

DOI:10.1016/s0920-9964(02)00333-x

PMID:12892872

Abstract

Markers of vulnerability have been identified in schizophrenia, and among them, neurological soft-signs (NSS) and minor physical anomalies (MPAs) also seem to occur in biological relatives. The similarities of these developmental markers within families may depend on either genetic or non-genetic factors. The aim of the study was to investigate the intra-familial similarities of NSS and MPAs within 18 nuclear families (18 probands with schizophrenia and 36 of their non-psychotic parents). A general linear model showed similarities within families for NSS (intra-class coefficient [ICC] = 0.64; F = 2.6; df = 17.17; p = 0.02) but not for MPAs (ICC = -0.10; F = 0.7; df = 17.17; ns). We thus found a direct evidence for the intra-familial transmission of NSS but not of MPAs, suggesting that this morphological phenotypic trait could be more dependent on epigenetic influences.

摘要

在精神分裂症中已确定了易感性标志物，其中，神经学软体征（NSS）和轻微身体异常（MPA）在生物学亲属中似乎也会出现。这些发育标志物在家族内部的相似性可能取决于遗传或非遗传因素。该研究的目的是调查18个核心家庭（18名精神分裂症先证者及其36名非精神病性父母）中NSS和MPA的家族内相似性。一个通用线性模型显示，家庭内部NSS存在相似性（组内系数[ICC]=0.64；F=2.6；自由度=17.17；p=0.02），但MPA不存在相似性（ICC=-0.10；F=0.7；自由度=17.17；无显著性差异）。因此，我们发现了NSS家族内传递的直接证据，但未发现MPA的家族内传递证据，这表明这种形态学表型特征可能更依赖于表观遗传影响。