Schröder J, Niethammer R, Geider F J, Reitz C, Binkert M, Jauss M, Sauer H
Department of Psychiatry, University of Heidelberg, F.R.G.
Schizophr Res. 1991 Dec;6(1):25-30. doi: 10.1016/0920-9964(91)90017-l.
A new scale for neurological soft signs (NSS) was constructed and consists of 17 items compiled from the literature. The scale was found to have a high internal reliability (Cronbach's alpha 0.83) and a high interrater reliability (0.88). According to the results of a factor analysis, NSS are covered by five factors: 'motor coordination', 'integrative functions', 'complex motor tasks', 'righ/left and spatial orientation' and 'hard signs'. Using this scale, the associations of NSS with clinical course and brain alterations were investigated. NSS varied with the clinical course and were significantly correlated with some BPRS subscales, in particular 'thought disorder'. In addition, the 'motor coordination' soft signs were found to correlate with morphological alterations in the basal ganglia.
构建了一种新的神经软体征（NSS）量表，该量表由从文献中选取的17个项目组成。结果发现该量表具有较高的内部信度（克朗巴哈系数α为0.83）和较高的评分者间信度（0.88）。根据因子分析结果，NSS涵盖五个因子：“运动协调”、“整合功能”、“复杂运动任务”、“左右及空间定向”和“硬体征”。使用该量表，研究了NSS与临床病程及脑改变之间的关联。NSS随临床病程而变化，且与简明精神病评定量表（BPRS）的一些子量表显著相关，尤其是“思维障碍”。此外，还发现“运动协调”软体征与基底神经节的形态学改变相关。
