Uchida Koji, Kumagai Takeshi
Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan.
Mol Aspects Med. 2003 Aug-Oct;24(4-5):213-8. doi: 10.1016/s0098-2997(03)00016-5.
4-hydroxy-2-nonenal (HNE) activates a variety of signaling pathways. We have recently evaluated the effect of oxidized fatty acid metabolites on cyclooxygenase-2 (COX-2) induction in rat liver epithelial RL34 cells and found that, among the compounds tested, HNE most dramatically induced COX-2. A p38 mitogen-activated protein kinase (p38 MAPK) pathway has been shown to play a key role in the mechanism of the HNE-induced COX-2 expression. It appears that the HNE-induced activation of p38 MAPK leads to the stabilization of COX-2 mRNA.
4-羟基-2-壬烯醛（HNE）可激活多种信号通路。我们最近评估了氧化脂肪酸代谢产物对大鼠肝上皮RL34细胞中环氧化酶-2（COX-2）诱导的影响，发现在所测试的化合物中，HNE最显著地诱导了COX-2。p38丝裂原活化蛋白激酶（p38 MAPK）通路已被证明在HNE诱导COX-2表达的机制中起关键作用。似乎HNE诱导的p38 MAPK激活导致了COX-2 mRNA的稳定。
