Goldberg Tamara B L, Rodrigues Maria A M, Takata Raquel T, Nogueira Célia R, Faleiros Antonio T S
Faculdade de Medicina Botucatu, Universidade Estadual de São Paulo, Botucatu, SP, Brasil.
Arq Neuropsiquiatr. 2003 Jun;61(2B):482-5. doi: 10.1590/s0004-282x2003000300030. Epub 2003 Jul 28.
Craniospinal radiation therapy for treatment of brain tumors may result in growth hormone (GH) insufficiency with resultant linear growth retardation, one of the most common complications. We report the case of a 10-year-old boy presenting headache associated to vertigo, nausea and vomiting. A CT scan showed an homogeneous mass in the left cerebelar hemisphere, that was surgically removed. The histopathological examination revealed medulloblastoma and the patient was submitted to craniospinal radiation. He did not present tumor recurrence nor neurological or cognitive deficits during 4 years, but evolved to short stature due to GH deficiency. Nowadays, he is being receiving GH 0,1 U/kg/day and has presented 4cm stature increment after 6 months. The present case highlights the importance in carefully monitoring of children after cranial radiation for oncologic treatment, because they may develop hormonal deficiencies, that can be successfully replaced.
颅脊髓放射治疗脑肿瘤可能会导致生长激素（GH）分泌不足，进而引起线性生长迟缓，这是最常见的并发症之一。我们报告了一例10岁男孩的病例，该男孩出现与眩晕、恶心和呕吐相关的头痛。CT扫描显示左小脑半球有一个均匀的肿块，已通过手术切除。组织病理学检查显示为髓母细胞瘤，患者接受了颅脊髓放射治疗。在4年期间，他没有出现肿瘤复发，也没有神经或认知缺陷，但由于生长激素缺乏而发育为身材矮小。如今，他正在接受每天0.1 U/kg的生长激素治疗，6个月后身高增加了4厘米。本病例强调了在肿瘤治疗后对接受颅脑放射治疗的儿童进行仔细监测的重要性，因为他们可能会出现激素缺乏，而这种缺乏可以得到成功替代。
