Brauner R, Czernichow P, Rappaport R, Lemerle J, Sarrazin D, Hirsch J F, Renier D, Zucker J M
Arch Fr Pediatr. 1985 Mar;42(3):219-23.
Treatment of medulloblastoma in children with head and spinal irradiation causes growth hormone deficiency and growth retardation. The present study deals with 45 patients presenting a follow-up time superior to 4 years; some of them having reached their final height. The mean final height is 3 standard deviations below normal mean. Growth retardation which occurred in 42 of 45 children, appears to be due to two major factors: 1) GH deficiency in 42 cases as assessed by the arginine insulin tolerance test. 2) Spinal lesions due to irradiation, causing early growth retardation and a reduced trunk length in most of these children. The response to hGH treatment (10 mg/kg/yr) was not sufficient in this group of patients.
对儿童髓母细胞瘤进行头部和脊髓照射治疗会导致生长激素缺乏和生长发育迟缓。本研究涉及45例随访时间超过4年的患者；其中一些患者已达到最终身高。平均最终身高比正常均值低3个标准差。45名儿童中有42名出现生长发育迟缓，这似乎是由两个主要因素导致的：1）通过精氨酸胰岛素耐量试验评估，42例存在生长激素缺乏。2）放疗引起的脊柱病变，导致这些儿童中的大多数出现早期生长发育迟缓以及躯干长度缩短。该组患者对生长激素治疗（10mg/kg/年）的反应并不充分。
