木霉纤维素酶形成的调控：来自一种工业真菌的分子生物学经验。综述
Regulation of Trichoderma cellulase formation: lessons in molecular biology from an industrial fungus. A review.
作者信息
Schmoll Monika, Kubicek C P
机构信息
Area Molecular Biotechnology, Section Applied Biochemistry and Gene Technology, Institute for Chemical Engineering, Vienna University of Technology, Getreidemarkt 9/1665, A-1060 Wien, Austria.
出版信息
Acta Microbiol Immunol Hung. 2003;50(2-3):125-45. doi: 10.1556/AMicr.50.2003.2-3.3.
The present article reviews the current understanding of regulation of cellulase gene transcription in Hypocrea jecorina (= Trichoderma reesei). Special emphasis is put on the mechanism of action of low molecular weight inducers of cellulase formation, the presence and role of recently identified transactivating proteins (Ace1, Ace2, Hap2/3/5), and the role of the carbon catabolite repressor Cre1. We also report on some recent genomic approaches towards understanding how cellulase inducers signal their presence to the transcriptional apparatus.
本文综述了目前对里氏木霉（= 绿色木霉）中纤维素酶基因转录调控的理解。特别强调了纤维素酶形成的低分子量诱导物的作用机制、最近鉴定出的反式激活蛋白（Ace1、Ace2、Hap2/3/5）的存在及作用，以及碳代谢物阻遏物Cre1的作用。我们还报道了一些最近的基因组学方法，旨在了解纤维素酶诱导物如何向转录装置传递它们存在的信号。
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