Matsumura Akira, Zhang Tian, Yamamoto Tetsuya, Yoshida Fumiyo, Sakurai Yoshinori, Shimojo Nobuhiro, Nose Tadao
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Anticancer Res. 2003 May-Jun;23(3B):2451-6.
In a previous study, we found that Gadobenate dimeglumine (Gd-BOPTA) resulted in a significantly greater Gd uptake by brain tumor tissue than Gadopentate dimeglumine (Gd-DTPA). Therefore, we investigated whether Gd-BOPTA is an efficient agent for neutron capture therapy (NCT).
Four groups of Fisher344 rats (control, neutron (n), n+ Gd-DTPA, n+ Gd-BOPTA) were subcutaneously injected 9L gliosarcoma cells in both hind legs. Gd-BOPTA and Gd-DTPA (0.05 mmol/g tumor weight) were injected directly into the tumor. At the peak of Gd uptake, thermal neutron irradiation was applied.
Two Gd+ groups showed pronounced tumor growth delay as compared with the control and neutron groups (p = 0.0053, 0.0064, respectively). Furthermore, the BOPTA group showed significantly prolonged delay of tumor growth as compared to the DTPA group (p = 0.033).
This is the first report of Gd-NCT to demonstrate that Gd-BOPTA serve as an effective compound for NCT. Better cytocidal effects of Gd-BOPTA warrant further investigation of subcellular Gd distribution.
在之前的一项研究中，我们发现钆布醇（Gd-BOPTA）导致脑肿瘤组织摄取的钆比钆喷酸葡胺（Gd-DTPA）显著更多。因此，我们研究了钆布醇是否是一种有效的中子俘获治疗（NCT）药物。
四组Fisher344大鼠（对照组、中子组（n）、n + Gd-DTPA组、n + Gd-BOPTA组）双侧后肢皮下注射9L胶质肉瘤细胞。将钆布醇和钆喷酸葡胺（0.05 mmol/g肿瘤重量）直接注射到肿瘤中。在钆摄取达到峰值时，施加热中子照射。
与对照组和中子组相比，两个钆+组均显示出明显的肿瘤生长延迟（分别为p = 0.0053，0.0064）。此外，与钆喷酸葡胺组相比，钆布醇组显示出显著延长的肿瘤生长延迟（p = 0.033）。
这是关于钆中子俘获治疗的首篇报道，证明钆布醇可作为中子俘获治疗的有效化合物。钆布醇更好的杀细胞效果值得进一步研究其亚细胞钆分布情况。
