Kondo Y, Kato A, Hojo H, Nozoe S, Takeuchi M, Ochi K
Pharmaceutical Institute, Tohoku University, Sendai, Japan.
J Pharmacobiodyn. 1992 Nov;15(11):617-21. doi: 10.1248/bpb1978.15.617.
Paramylon, a beta-(1-->3)-D-glucan, isolated from Euglena gracilis, was tested for its adjuvant activity on the antibody response to sheep red blood cell (SRBC) in mice. Paramylon markedly enhanced anti-SRBC plaque-forming cell production at a dose of 10 mg/kg. It was also found that in vitro addition of lipopolysaccharide in culture to macrophages from paramylon-treated mice produced a large amount of interleukin 1 (IL-1) and there was a significant level of interleukin 6 (IL-6) induced transiently in the blood of these mice. As IL-1 and IL-6 play crucial roles in the immune response to T cell-dependent antigens like SRBC, the immunopotentiating effect of paramylon might be expressed through the action of these cytokines.
从纤细裸藻中分离出的β-(1→3)-D-葡聚糖——副淀粉，对其在小鼠体内针对绵羊红细胞（SRBC）抗体反应的佐剂活性进行了测试。副淀粉以10毫克/千克的剂量显著增强了抗SRBC斑块形成细胞的产生。还发现，在体外培养中向用副淀粉处理过的小鼠的巨噬细胞添加脂多糖会产生大量白细胞介素1（IL-1），并且在这些小鼠的血液中短暂诱导出显著水平的白细胞介素6（IL-6）。由于IL-1和IL-6在针对像SRBC这样的T细胞依赖性抗原的免疫反应中起关键作用，副淀粉的免疫增强作用可能是通过这些细胞因子的作用来表达的。
