Olsen E, Stenn K, Bergfeld W, Cotsarelis G, Price V, Shapiro J, Sinclair R, Solomon A, Sperling L, Whiting D
Duke University Medical Center, Durham, NC 27710, USA.
J Investig Dermatol Symp Proc. 2003 Jun;8(1):18-9. doi: 10.1046/j.1523-1747.2003.12166.x.
Cicatricial alopecia is an enigmatic group of hair disorders linked by the potential permanent loss of scalp hair follicles in involved areas. Progress in our understanding and treatment of these disorders has been stymied by the lack of clear diagnostic criteria for the current terms used to describe the various hair loss entities. Since all of these conditions evolve as the hair is destroyed or replaced, diagnosis is further made difficult by a lack of clinical and pathologic "snapshots" over the evolution of each disorder. Without some acceptance of general clinical and histological presentations in the early, mid and late stage of these disorders, one cannot begin to explore ways to make the diagnosis at a very early stage before significant follicular destraction has occurred (making the clinical diagnosis obvious) and when the damage is potentially repairable or progression preventable.
瘢痕性脱发是一组神秘的毛发疾病,其共同特点是受累区域的头皮毛囊可能会永久性丧失。由于用于描述各种脱发实体的现有术语缺乏明确的诊断标准,我们对这些疾病的理解和治疗进展受到了阻碍。由于所有这些情况都是在毛发被破坏或替换的过程中演变的,每种疾病演变过程中缺乏临床和病理“快照”,这进一步增加了诊断的难度。如果不了解这些疾病早期、中期和晚期的一般临床和组织学表现,就无法在毛囊严重受损(使临床诊断变得明显)之前的非常早期阶段,即损伤可能可修复或进展可预防的时候,开始探索诊断方法。