Goenjian Armen K, Pynoos Robert S, Steinberg Alan M, Endres David, Abraham Khachik, Geffner Mitchell E, Fairbanks Lynn A
Department of Psychiatry and Biobehavioral Sciences, UCLA/Duke University National Center for Child Traumatic Stress, UCLA School of Medicine Los Angles, California 90064, USA.
J Trauma Stress. 2003 Aug;16(4):319-23. doi: 10.1023/A:1024453632458.
This study evaluated basal levels and responsiveness to exercise of plasma adrenocorticotropic hormone (ACTH), and serum thyroid stimulating hormone (TSH), growth hormone (GH) and cortisol among adolescents from two differentially exposed groups 6 1/2 years after the 1988 earthquake in Armenia. Severity of total PTSD and Category C and D symptoms were negatively correlated with baseline cortisol. Preexercise ACTH was significantly lower, and preexercise TSH higher, among adolescents with more exposure. Depressive symptoms were negatively correlated with baseline cortisol and positively with TSH. Mean GH, TSH, and cortisol levels in both groups fell within normal limits. The pre- to postexercise increase in GH, TSH, and cortisol suggests that exercise challenge may be useful in the field investigation of neurohormonal activity among traumatized individuals.
本研究评估了1988年亚美尼亚地震6年半后，来自两个不同暴露组的青少年血浆促肾上腺皮质激素（ACTH）、血清促甲状腺激素（TSH）、生长激素（GH）和皮质醇的基础水平及对运动的反应性。创伤后应激障碍（PTSD）总分及C类和D类症状的严重程度与基线皮质醇呈负相关。暴露程度较高的青少年运动前ACTH显著较低，运动前TSH较高。抑郁症状与基线皮质醇呈负相关，与TSH呈正相关。两组的平均GH、TSH和皮质醇水平均在正常范围内。运动前后GH、TSH和皮质醇的升高表明，运动挑战可能有助于对受创伤个体的神经激素活动进行现场调查。
