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Randomised trial to assess benefits and safety of vitamin A supplementation linked to immunisation in early infancy. WHO/CHD Immunisation-Linked Vitamin A Supplementation Study Group.评估婴儿早期与免疫接种相关的维生素A补充剂的益处和安全性的随机试验。世界卫生组织/儿童健康与发展司免疫接种相关维生素A补充剂研究组
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本文引用的文献

1
Maternal low-dose vitamin A or beta-carotene supplementation has no effect on fetal loss and early infant mortality: a randomized cluster trial in Nepal.孕期补充低剂量维生素A或β-胡萝卜素对胎儿死亡和婴儿早期死亡率无影响：尼泊尔的一项随机整群试验
Am J Clin Nutr. 2000 Jun;71(6):1570-6. doi: 10.1093/ajcn/71.6.1570.
2
Maternal vitamin A or beta-carotene supplementation in lactating bangladeshi women benefits mothers and infants but does not prevent subclinical deficiency.孟加拉国哺乳期妇女补充维生素A或β-胡萝卜素对母亲和婴儿有益，但不能预防亚临床缺乏。
J Nutr. 1999 Feb;129(2):356-65. doi: 10.1093/jn/129.2.356.
3
Randomised trial to assess benefits and safety of vitamin A supplementation linked to immunisation in early infancy. WHO/CHD Immunisation-Linked Vitamin A Supplementation Study Group.评估婴儿早期与免疫接种相关的维生素A补充剂的益处和安全性的随机试验。世界卫生组织/儿童健康与发展司免疫接种相关维生素A补充剂研究组
Lancet. 1998 Oct 17;352(9136):1257-63.
4
Impact of neonatal vitamin A supplementation on infant morbidity and mortality.新生儿补充维生素A对婴儿发病率和死亡率的影响。
J Pediatr. 1996 Apr;128(4):489-96. doi: 10.1016/s0022-3476(96)70359-1.
5
High dose vitamin A supplementation of breast-feeding Indonesian mothers: effects on the vitamin A status of mother and infant.印度尼西亚哺乳期母亲高剂量补充维生素A：对母婴维生素A状况的影响。
J Nutr. 1993 Apr;123(4):666-75. doi: 10.1093/jn/123.4.666.
6
In vitamin A deficiency multiple mechanisms establish a regulatory T helper cell imbalance with excess Th1 and insufficient Th2 function.在维生素A缺乏症中，多种机制会导致调节性T辅助细胞失衡，Th1功能过剩而Th2功能不足。
J Immunol. 1994 Feb 15;152(4):1515-22.
7
Vitamin A supplementation in northern Ghana: effects on clinic attendances, hospital admissions, and child mortality. Ghana VAST Study Team.加纳北部补充维生素A：对门诊就诊、住院及儿童死亡率的影响。加纳大规模维生素A研究团队
Lancet. 1993 Jul 3;342(8862):7-12.
8
Abnormal T-cell subset proportions in vitamin-A-deficient children.
Lancet. 1993 Jan 2;341(8836):5-8. doi: 10.1016/0140-6736(93)92478-c.
9
Mortality of infants < 6 mo of age supplemented with vitamin A: a randomized, double-masked trial in Nepal.补充维生素A的6个月龄以下婴儿的死亡率：尼泊尔的一项随机双盲试验。
Am J Clin Nutr. 1995 Jul;62(1):143-8. doi: 10.1093/ajcn/62.1.143.
10
Plasma vitamin A and retinol-binding protein in premature and term neonates.早产儿和足月儿的血浆维生素A及视黄醇结合蛋白
J Pediatr. 1981 Aug;99(2):302-5. doi: 10.1016/s0022-3476(81)80484-2.

给新生儿补充维生素A对婴儿早期死亡率的影响：印度南部基于社区的随机试验。

Impact of supplementing newborn infants with vitamin A on early infant mortality: community based randomised trial in southern India.

作者信息

Rahmathullah Lakshmi, Tielsch James M, Thulasiraj R D, Katz Joanne, Coles Christian, Devi Sheela, John Rajeesh, Prakash Karthik, Sadanand A V, Edwin N, Kamaraj C

机构信息

Aravind Centre for Women, Children and Community Health, Madurai, Tamil Nadu, India.

出版信息

BMJ. 2003 Aug 2;327(7409):254. doi: 10.1136/bmj.327.7409.254.

DOI:10.1136/bmj.327.7409.254
PMID:12896935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC167159/
Abstract

OBJECTIVE

To assess the impact of supplementing newborn infants with vitamin A on mortality at age 6 months.

DESIGN

Community based, randomised, double blind, placebo controlled trial.

SETTING

Two rural districts of Tamil Nadu, southern India.

PARTICIPANTS

11 619 newborn infants allocated 24 000 IU oral vitamin A or placebo on days 1 and 2 after delivery.

MAIN OUTCOME MEASURE

Primary outcome measure was mortality at age 6 months.

RESULTS

Infants in the vitamin A group had a 22% reduction in total mortality (95% confidence interval 4% to 37%) compared with those in the placebo group. Vitamin A had an impact on mortality between two weeks and three months after treatment, with no additional impact after three months.

CONCLUSION

Supplementing newborn infants with vitamin A can significantly reduce early infant mortality.

摘要

目的

评估给新生儿补充维生素A对6个月龄时死亡率的影响。

设计

基于社区的随机双盲安慰剂对照试验。

地点

印度南部泰米尔纳德邦的两个农村地区。

参与者

11619名新生儿在出生后第1天和第2天被分配口服24000国际单位维生素A或安慰剂。

主要结局指标

主要结局指标是6个月龄时的死亡率。

结果

与安慰剂组相比，维生素A组的总死亡率降低了22%（95%置信区间为4%至37%）。维生素A对治疗后两周至三个月之间的死亡率有影响，三个月后无额外影响。

结论

给新生儿补充维生素A可显著降低早期婴儿死亡率。