West K P, Katz J, Shrestha S R, LeClerq S C, Khatry S K, Pradhan E K, Adhikari R, Wu L S, Pokhrel R P, Sommer A
Department of International Health, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA.
Am J Clin Nutr. 1995 Jul;62(1):143-8. doi: 10.1093/ajcn/62.1.143.
The effect of supplementing 11,918 infants < 1 mo and 1-5 mo of age with vitamin A (15,000 and 30,000 micrograms retinol equivalents or 50,000 and 100,000 IU, respectively) or a placebo on subsequent 4-mo mortality was assessed in a randomized, double-masked community trial in the rural plains of Nepal. There were 130 deaths (51.6/1000 child-y) in the control group and 150 deaths (57.1/1000 child-y) in the vitamin A group, yielding a relative risk of 1.11 (95% CI: 0.86, 1.42), which is indicative of no overall effect on early infant mortality. There was a tendency for the relative risk of mortality among vitamin A recipients to rise with improved nutritional status. These results suggest that distribution of a large oral dose of vitamin A to infants < 5-6 mo of age may not benefit short-term survival. This is in contrast with the results of trials in which older infants and children in this same population were supplemented.
在尼泊尔平原农村进行的一项随机、双盲社区试验中，评估了给11918名1月龄以下及1 - 5月龄婴儿补充维生素A（分别为15000和30000微克视黄醇当量或50000和100000国际单位）或安慰剂对随后4个月死亡率的影响。对照组有130例死亡（51.6/1000儿童年），维生素A组有150例死亡（57.1/1000儿童年），相对风险为1.11（95%置信区间：0.86，1.42），这表明对早期婴儿死亡率没有总体影响。维生素A补充组的死亡相对风险有随着营养状况改善而上升的趋势。这些结果表明，给5 - 6月龄以下婴儿大剂量口服维生素A可能对短期生存没有益处。这与在同一人群中对较大婴儿和儿童进行补充的试验结果相反。
