Ribozyme-mediated revision of RNA and DNA.
作者信息
Long Meredith B, Jones J P, Sullenger Bruce A, Byun Jonghoe
机构信息
Department of Surgery, Duke University Medical Center, Box 2601, Durham, North Carolina 27710, USA.
出版信息
J Clin Invest. 2003 Aug;112(3):312-8. doi: 10.1172/JCI19386.
Abstract
摘要
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Ribozyme-mediated selective induction of new gene activity in hepatitis C virus internal ribosome entry site-expressing cells by targeted trans-splicing.核酶介导的靶向反式剪接在丙型肝炎病毒内部核糖体进入位点表达细胞中选择性诱导新基因活性
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Functional repair of a mutant chloride channel using a trans-splicing ribozyme.使用反式剪接核酶对突变氯离子通道进行功能修复。
J Clin Invest. 2002 Dec;110(12):1783-9. doi: 10.1172/JCI16481.
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Mol Ther. 2000 Sep;2(3):245-55. doi: 10.1006/mthe.2000.0125.
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Group II introns designed to insert into therapeutically relevant DNA target sites in human cells.第二组内含子被设计用于插入人类细胞中与治疗相关的DNA靶位点。
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