Heller Theo, Hoofnagle Jay H
Liver Diseases Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
J Clin Invest. 2003 Aug;112(3):319-21. doi: 10.1172/JCI19417.
Hepatitis delta virus (HDV) is a cause of acute and chronic liver disease for which no effective therapy is currently available. Previous research has demonstrated that prenylation of the large HDV antigen is essential for viral assembly. A new report describes a novel small animal model for HDV replication and demonstrates that prenylation inhibitors are highly effective at clearing viremia and thus have potential relevance for the treatment of chronic delta hepatitis.
丁型肝炎病毒(HDV)是急性和慢性肝病的一个病因,目前尚无有效的治疗方法。先前的研究表明,大型HDV抗原的异戊二烯化对于病毒组装至关重要。一项新报告描述了一种用于HDV复制的新型小动物模型,并证明异戊二烯化抑制剂在清除病毒血症方面非常有效,因此对慢性丁型肝炎的治疗可能具有重要意义。