Wang K S, Choo Q L, Weiner A J, Ou J H, Najarian R C, Thayer R M, Mullenbach G T, Denniston K J, Gerin J L, Houghton M
Nature. 1986;323(6088):508-14. doi: 10.1038/323508a0.
Biochemical and electron microscopic data indicate that the human hepatitis delta viral agent contains a covalently closed circular and single-stranded RNA genome that has certain similarities with viroid-like agents from plants. The sequence of the viral genome (1,678 nucleotides) has been determined and an open reading frame within the complementary strand has been shown to encode an antigen that binds specifically to antisera from patients with chronic hepatitis delta viral infections.
生化和电子显微镜数据表明，人类丁型肝炎病毒因子含有一个共价闭合环状单链RNA基因组，该基因组与植物类病毒因子有一定相似性。病毒基因组序列（1678个核苷酸）已被确定，互补链中的一个开放阅读框已被证明可编码一种抗原，该抗原能与慢性丁型肝炎病毒感染患者的抗血清特异性结合。
