白细胞介素-13与腺苷：分子之舞中的伙伴？
IL-13 and adenosine: partners in a molecular dance?
作者信息
Grünig Gabriele
机构信息
Department of Pathology, St Luke's Roosevelt Hospital, New York, New York 10019, USA.
出版信息
J Clin Invest. 2003 Aug;112(3):329-31. doi: 10.1172/JCI19392.
Abstract
Inflammation and airway remodeling are two responses readily apparent in asthma and other inflammatory disorders of the airway and lungs. Both adenosine and IL-13 play critical roles in contributing pathways. A new study reveals a previously unrecognized interaction between adenosine and IL-13 that indicates a mutual stimulation that may contribute to the nature and severity of airway inflammation and fibrosis.
摘要
炎症和气道重塑是哮喘及其他气道和肺部炎症性疾病中两种明显的反应。腺苷和白细胞介素-13在促成这些反应的途径中都起着关键作用。一项新研究揭示了腺苷和白细胞介素-13之间一种此前未被认识到的相互作用，这种相互作用表明存在一种相互刺激，可能会影响气道炎症和纤维化的性质及严重程度。
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