等待“开”期：帕金森病患者及“开/关”运动波动的一个主要问题。
Waiting for ON: a major problem in patients with Parkinson disease and ON/OFF motor fluctuations.
作者信息
Merims Doron, Djaldetti Ruth, Melamed Eldad
机构信息
Department of Neurology, Rabin Medical Center, Beilinson Campus, Petah Tiqva 49100, Israel.
出版信息
Clin Neuropharmacol. 2003 Jul-Aug;26(4):196-8. doi: 10.1097/00002826-200307000-00009.
The authors compared the two portions of the OFF period in patients with Parkinson disease and response fluctuations: time to ON (the latency from levodopa intake to turning ON) and wearing off (time from termination of the beneficial dose effect until the time when the next dose was taken). Time to ON was more than twice the duration of wearing off. Although underrecognized, time to ON is the major component of total daily OFF.
作者比较了帕金森病患者“关”期的两个阶段以及反应波动情况：起效时间（从摄入左旋多巴到起效的延迟时间）和药效消退时间（从有益剂量效应终止到下次服药的时间）。起效时间是药效消退时间的两倍多。尽管未得到充分认识，但起效时间是每日总“关”期的主要组成部分。
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