Bussen Stefanie, Sütterlin Marc, Steck Thomas, Dietl Johannes
Department of Obstetrics and Gynecology, University of Würzburg, Josef-Schneider-Strasse 4, 97080 Würzburg, Germany.
Arch Gynecol Obstet. 2004 Mar;269(3):196-8. doi: 10.1007/s00404-003-0493-x. Epub 2003 Jul 25.
The aim of our study was to evaluate pretreatment semen quality in patients with unilateral testicular cancer in comparison to semen parameters of patients suffering from other malignancies.
Semen analysis according to WHO recommendations were performed in 16 patients suffering from unilateral testicular cancer (group 1) and in 21 patients who were diagnosed to have other malignant tumors (group 2: non-Hodgkin's lymphoma: n=7, Hodgkin's disease: n=6, leukemia: n=3, osteosarcoma: n=2, rectal cancer: n=2, thyroid carcinoma: n=1) prior to anti-cancer treatment.
Normozoospermia was observed in none of the testicular cancer patients but in five of the other patients ( p=0.047). Sperm concentration was significantly decreased in the patients of group 1 compared to those of group 2 (18.7+/-22.3x10(6)/ml versus 35.6+/-31.3x10(6)/ml, p=0.03). The percentage of rapid progressive motile spermatozoa was significantly less in testicular cancer patients than in patients suffering from other malignancies (WHO group a: 1.1+/-2.0% versus 4.7+/-5.6%, p=0.02). Normal morphological findings of spermatozoa were found in a smaller percentage in group 1 (16.2+/-6.0% versus 26.1+/-18.0%, p=0.03).
Our investigations revealed that especially testicular cancer has an adverse influence on sperm quality. Hence, we advise careful and sufficient cryopreservation of semen in those patients taking the negative impact of cytotoxic treatments on semen parameters into account.
我们研究的目的是评估单侧睾丸癌患者的预处理精液质量，并与其他恶性肿瘤患者的精液参数进行比较。
按照世界卫生组织的建议，对16例单侧睾丸癌患者（第1组）和21例被诊断患有其他恶性肿瘤的患者（第2组：非霍奇金淋巴瘤：n = 7，霍奇金病：n = 6，白血病：n = 3，骨肉瘤：n = 2，直肠癌：n = 2，甲状腺癌：n = 1）在抗癌治疗前进行精液分析。
睾丸癌患者中未观察到正常精子症，但其他患者中有5例观察到（p = 0.047）。与第2组患者相比，第1组患者的精子浓度显著降低（18.7±22.3×10⁶/ml对35.6±31.3×10⁶/ml，p = 0.03）。睾丸癌患者中快速前向运动精子的百分比显著低于其他恶性肿瘤患者（世界卫生组织a组：1.1±2.0%对4.7±5.6%，p = 0.02）。第1组中精子正常形态的比例较小（16.2±6.0%对26.1±18.0%，p = 0.03）。
我们的研究表明，尤其是睾丸癌对精子质量有不利影响。因此，考虑到细胞毒性治疗对精液参数的负面影响，我们建议对这些患者进行仔细和充分的精液冷冻保存。
