Padron O F, Sharma R K, Thomas A J, Agarwal A
Department of Urology, Cleveland Clinic Foundation, Ohio 44195, USA.
Fertil Steril. 1997 Feb;67(2):326-31. doi: 10.1016/S0015-0282(97)81919-X.
To determine whether type of cancer and response to treatment was related to prefreeze or post-thaw semen quality and to predict post-thaw sperm motility from prefreeze motility.
Retrospective study.
Tertiary care institution.
PATIENT(S): One hundred six cancer patients cryopreserving their semen specimens.
INTERVENTION(S): Computer-assisted semen analysis was performed before and after cryopreservation on each patient specimen.
MAIN OUTCOME MEASURE(S): The relationship of sperm motility and motion characteristics to type of cancer and patient's response to treatment.
RESULT(S): Prefreeze and post-thaw semen quality did not differ between patients presenting with testicular cancer and Hodgkin's disease. Patients with leukemia or advanced soft tissue cancer had a higher prefreeze and post-thaw motility and higher total and motile sperm count than testicular and Hodgkin's disease patients. A prefreeze sperm motility of > or = 15% could predict a post-thaw motility of > 10%.
CONCLUSION(S): Prefreeze or post-thaw semen quality in cancer patients is not affected (except the prefreeze motile sperm count within the testicular cancer patients) by the type of disease. Prefreeze motility can predict post-thaw motility. Cryopreservation of semen should be offered to cancer patients irrespective of the type of disease.
确定癌症类型及治疗反应是否与冻精前或解冻后精液质量相关，并根据冻精前精子活力预测解冻后精子活力。
回顾性研究。
三级医疗机构。
106例癌症患者冻存其精液标本。
对每位患者的标本在冻存前后进行计算机辅助精液分析。
精子活力和运动特征与癌症类型及患者治疗反应的关系。
睾丸癌和霍奇金病患者的冻精前和解冻后精液质量无差异。白血病或晚期软组织癌患者的冻精前和解冻后活力以及总精子数和活动精子数均高于睾丸癌和霍奇金病患者。冻精前精子活力≥15%可预测解冻后活力>10%。
疾病类型不影响（睾丸癌患者的冻精前活动精子数除外）癌症患者的冻精前或解冻后精液质量。冻精前活力可预测解冻后活力。无论疾病类型如何，均应向癌症患者提供精液冻存服务。
