Zółkowska Dorota, Pikuła Anna, Borzecki Andrzej, Sieklucka-Dziuba Maria
Department of Hygiene, Medical University of Lublin.
Ann Univ Mariae Curie Sklodowska Med. 2002;57(1):569-73.
Local anesthetics are widely used in alleviating pain concomitant with small surgery procedures and in dentistry. Especially medication in ductal anesthesia after penetrating into systemic circulation can have significant influence on the central nervous system and stimulus conduction in the heart. Clonidine and reserpine are centrally acting antihypertensive drugs. The aim of this study was to examine an interaction of lidocaine, articaine and mepivacaine with some antihypertensive drugs clonidine and reserpine on the pentylenetetrazole induced seizures.
articaine is the most safe local anesthetic and can be used in epileptic patients Co-administration of local anesthetics with centrally acting antihypertensive drugs did not influence seizures activity in mice.
局部麻醉药广泛用于缓解小型手术和牙科手术伴随的疼痛。尤其是在导管麻醉中，药物进入体循环后会对中枢神经系统和心脏的刺激传导产生重大影响。可乐定和利血平是中枢作用的抗高血压药物。本研究的目的是研究利多卡因、阿替卡因和甲哌卡因与一些抗高血压药物可乐定和利血平在戊四氮诱发惊厥方面的相互作用。
阿替卡因是最安全的局部麻醉药，可用于癫痫患者。局部麻醉药与中枢作用的抗高血压药物联合使用不会影响小鼠的惊厥活动。
