Kim K C, Tasch M D
Anesth Analg. 1986 Aug;65(8):840-2.
The effects of cimetidine (5-200 mg/kg), ranitidine (1-100 mg/kg), or saline on local anesthetic central nervous system toxicity was studied when administered 20 min before the administration of lidocaine (30-80 mg/kg) or 2-chloroprocaine (50-250 mg/kg) to female white CD-1 mice. All drugs were administered intraperitoneally. The 50% convulsive dose (CD50) was determined for each drug and dose combination. Pretreatment with cimetidine resulted in a significant, dose-dependent decrease in the CD50 of lidocaine, whereas ranitidine pretreatment did not significantly alter the lidocaine CD50. A dose of cimetidine (15 mg/kg) that caused a significant decrease in 2-chloroprocaine CD50 (from 180 to 110 mg/kg) caused only an insignificant decrease in lidocaine CD50 (from 59 to 54 mg/kg). If these results can be applied to clinical doses in humans, ranitidine may be a safer premedicant than cimetidine with regard to interactions with local anesthetics.
在向雌性白色CD-1小鼠腹腔注射利多卡因（30 - 80mg/kg）或2 - 氯普鲁卡因（50 - 250mg/kg）前20分钟，研究西咪替丁（5 - 200mg/kg）、雷尼替丁（1 - 100mg/kg）或生理盐水对局部麻醉药中枢神经系统毒性的影响。所有药物均经腹腔注射。测定每种药物和剂量组合的50%惊厥剂量（CD50）。西咪替丁预处理导致利多卡因的CD50显著降低且呈剂量依赖性，而雷尼替丁预处理未显著改变利多卡因的CD50。导致2 - 氯普鲁卡因CD50显著降低（从180mg/kg降至110mg/kg）的西咪替丁剂量（15mg/kg），仅使利多卡因的CD50出现不显著降低（从59mg/kg降至54mg/kg）。如果这些结果可应用于人类临床剂量，那么在与局部麻醉药相互作用方面，雷尼替丁可能比西咪替丁是更安全的术前用药。
