Vishnevskiĭ B I, Vishnevskaia E B
Probl Tuberk Bolezn Legk. 2003(5):42-5.
The morbidity of primary and secondary drug resistance (DR) of Mycobacterium tuberculosis (MBT) was studied in the North-West of Russia during 1991-2001. The frequency rate and structure of, mainly, secondary DR MBT was investigated in tuberculosis of different localizations on the basis of data provided by clinics of Saint-Petersburg Research Institute for Phthisiopulmonology (PRIP) during 1990-2000. A sharp increase of primary DR MBT (in the North-West of Russia) up to 35-45.5% was detected in the Murmansk, Arkhangelsk and Saint-Petersburg Regions as well as in the Republic of Karelia, an increase of up to 61% was registered in the Kaliningrad Region. The frequency rate of secondary DR MBT went up by 1.5-2 times reaching 80-86% in the Murmansk, Arkhangelsk and Kaliningrad Regions. According to the PRIP clinics, there is also an essential growth of DR MBT in all tuberculosis localizations with a trend of the stability structure shifting towards poly-resistance, which accounts for 65.2% in pulmonary tuberculosis and for 33.6% in extra-pulmonary tuberculosis.
1991年至2001年期间，对俄罗斯西北部结核分枝杆菌（MBT）的原发性和继发性耐药性（DR）发病率进行了研究。根据圣彼得堡肺病研究所（PRIP）诊所1990年至2000年提供的数据，对不同部位结核病中主要是继发性DR MBT的发生率和结构进行了调查。在摩尔曼斯克、阿尔汉格尔斯克和圣彼得堡地区以及卡累利阿共和国，检测到俄罗斯西北部原发性DR MBT急剧增加至35%-45.5%，加里宁格勒地区则高达61%。摩尔曼斯克、阿尔汉格尔斯克和加里宁格勒地区继发性DR MBT的发生率上升了1.5至2倍，达到80%-86%。根据PRIP诊所的数据，所有结核病部位的DR MBT也有显著增长，且结构稳定向多药耐药转变，这在肺结核中占65.2%，在肺外结核中占33.6%。
