Nesković Vojislava, Milojević Predrag
Institut za kardiovaskularne bolesti Dedinje, 11040 Beograd, Milana Tepića 1.
Med Pregl. 2003 Mar-Apr;56(3-4):152-6. doi: 10.2298/mpns0304152n.
High thoracic epidural anesthesia and analgesia are being increasingly used for coronary artery bypass graft surgery. The reasons for this include excellent perioperative pain control with advantage of early tracheal extubation, improved postoperative pulmonary function, and cardiac protection due to sympthatetic blockade.
Cardiac protection is the consequence of decreased heart rate, myocardial contractility and arterial blood pressure, without changes in coronary perfusion pressure. Therefore, high thoracic epidural analgesia beneficially alters major determinants of myocardial oxygen consumption, without jeopardizing coronary perfusion pressure. In addition, decrease of functional residual capacity, may reduce postoperative pulmonary morbidity.
Patients with high thoracic epidural anesthesia revealed a more favourable perioperative hemodynamic profile, lower incidence of ischemia and better response to perioperative stress.
The epidural catheter should be placed at the Th2/Th3 interspace at least one hour before administration of heparin. After local anesthetic bolus dose, a continuous epidural infusion is recommended.
There is strong evidence for beneficial effects of high thoracic epidural anesthesia in patients undergoing surgical myocardial revascularization. However, it is still underutilized in current clinical practice.
高位胸椎硬膜外麻醉和镇痛在冠状动脉搭桥手术中的应用越来越广泛。其原因包括围手术期疼痛控制良好,具有早期气管拔管的优势,术后肺功能改善,以及交感神经阻滞带来的心脏保护作用。
心脏保护作用源于心率、心肌收缩力和动脉血压降低,而冠状动脉灌注压不变。因此,高位胸椎硬膜外镇痛有益地改变了心肌耗氧量的主要决定因素,同时不危及冠状动脉灌注压。此外,功能残气量减少可能降低术后肺部并发症的发生率。
接受高位胸椎硬膜外麻醉的患者围手术期血流动力学表现更有利,缺血发生率更低,对围手术期应激的反应更好。
硬膜外导管应在给予肝素前至少1小时置于胸2/胸3间隙。给予局部麻醉药推注剂量后,建议进行持续硬膜外输注。
有充分证据表明高位胸椎硬膜外麻醉对接受外科心肌血运重建的患者有益。然而,在目前的临床实践中其仍未得到充分利用。