Suzuki K, Satoh Y, Lei L, Ohta S, Urano T, Nakagata N, Yamada G
Center for Animal Resources and Development, Kumamoto University, Honjo 2-2-1, 860-0811, Kumamoto, Japan.
Cell Mol Biol (Noisy-le-grand). 2003 Jun;49(4):653-60.
It has been postulated many times that different scientific topics and strategies often encounter each other, which create cutting edge research field resulting in further significant progresses of science. This was also a lesson bestowed by Prof. Raymond Wegmann where he created innovative research field for biology, molecular biology and biochemistry-biophysics. Progresses of developmental biology were boosted by molecular biology and reproductive engineering where ES cells and embryonic manipulation are necessary. There are no questions about the utility of their technologies. Reviews on their contributions with respect to the condition of genome manipulation are addressed.
人们多次推测，不同的科学主题和策略常常相互碰撞，从而形成前沿研究领域，推动科学取得进一步重大进展。这也是雷蒙德·韦格曼教授所传授的经验，他开创了生物学、分子生物学以及生物化学与生物物理学的创新研究领域。发育生物学的进展因分子生物学和生殖工程而得到推动，其中胚胎干细胞和胚胎操作是必不可少的。这些技术的实用性毋庸置疑。本文将探讨它们在基因组操作条件方面的贡献。
