Mullington J M, Chan J L, Van Dongen H P A, Szuba M P, Samaras J, Price N J, Meier-Ewert H K, Dinges D F, Mantzoros C S
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
J Neuroendocrinol. 2003 Sep;15(9):851-4. doi: 10.1046/j.1365-2826.2003.01069.x.
The aim of the current study was to investigate the effects of sleep loss on the diurnal rhythm of circulating leptin levels. An indwelling forearm catheter was used to sample blood at 90-min intervals for a total of 120 h, which included 88 h of sustained sleeplessness, in 10 healthy men. The diurnal amplitude of leptin was reduced during total sleep deprivation and returned toward normal during the period of recovery sleep. This finding provides evidence that sleep influences the nocturnal leptin profile, and may have implications for the understanding of the role of sleep in metabolic regulation and the aetiologies of obesity and the night eating syndrome.
本研究的目的是调查睡眠缺失对循环瘦素水平昼夜节律的影响。在10名健康男性中，使用留置前臂导管以90分钟的间隔采集血液，共采集120小时，其中包括88小时的持续无睡眠状态。在完全睡眠剥夺期间，瘦素的昼夜振幅降低，在恢复睡眠期间恢复正常。这一发现证明睡眠会影响夜间瘦素水平，可能有助于理解睡眠在代谢调节中的作用以及肥胖和夜食综合征的病因。
