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行为评估与研究系统(BARS)的开发,用于检测和表征人类神经毒性。

Development of the Behavioral Assessment and Research System (BARS) to detect and characterize neurotoxicity in humans.

作者信息

Rohlman Diane S, Gimenes Lincoln S, Eckerman David A, Kang Seong-Kyu, Farahat Fayssal M, Anger W Kent

机构信息

CROET L606, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

出版信息

Neurotoxicology. 2003 Aug;24(4-5):523-31. doi: 10.1016/s0161-813x(03)00023-8.

DOI:10.1016/s0161-813x(03)00023-8
PMID:12900065
Abstract

The Behavioral Assessment and Research System (BARS) is a computer-based testing system designed to assess neurobehavioral function in humans. It was developed to provide a series or battery of neurobehavioral tests optimized for the detection of neurotoxicity in non-mainstream human populations, specifically people with limited education or literacy. Key to meeting this goal were simply-stated instructions divided into an elemental series of steps, a 9BUTTON response unit to replace the computer keyboard for responding, and spoken instructions. Modifications all underwent serial testing in target populations to successively hone the changes to be more effective. A similar process was followed when developing adjustable parameters, test reliability assessments, and when implementing these tests with populations from different cultural groups and children. The principles and experiences that guided the development of BARS should inform the development of future testing systems to ensure that the new tests can be used with non-mainstream populations, which may be increasingly subject to neurotoxic exposures.

摘要

行为评估与研究系统(BARS)是一个基于计算机的测试系统,旨在评估人类的神经行为功能。它的开发是为了提供一系列或一套针对非主流人群(特别是受教育程度或识字能力有限的人群)检测神经毒性而优化的神经行为测试。实现这一目标的关键在于将简单明了的说明分为一系列基本步骤,使用一个9键响应单元取代计算机键盘进行响应,并提供语音说明。所有修改都在目标人群中进行了系列测试,以不断完善这些更改,使其更有效。在开发可调参数、测试可靠性评估以及对来自不同文化群体的人群和儿童实施这些测试时,也遵循了类似的过程。指导BARS开发的原则和经验应为未来测试系统的开发提供参考,以确保新测试能够用于可能越来越容易受到神经毒性暴露影响的非主流人群。

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