Guazzi M, Polese A, Magrini F, Fiorentini C, Olivari M T
Am J Med Sci. 1975 Nov-Dec;270(3):465-74. doi: 10.1097/00000441-197511000-00007.
Twelve men suffering from the primary hyperkinetic heart syndrome (PHHS) displayed palpitation, rapid and forceful heart action, increased pulsations of the large arteries, cardiac systolic murmur, and the following circulatory values (averages): systolic arterial pressure (SAP) =154 mm Hg; heart rate (HR)=91 b/min; cardiac index (Ci) =5494 ml/min/m2; left ventricular mean systolic ejection rate index (SMEJR) =227 ml/min/m2; left ventricular mean pre-ejection delta P/delta t (delta P/delta t) = 1.32 mm Hg/msec. A two-year followup during which propranolol was administered (80-160 mg/day) revealed good subjective improvement and disappearance of signs of circulatory hyperkinesis. At the end of this period the hemodynamic functions were as follows: SAP=134; HR=69; Cl=3489; MSEJR=171; delta P/delta t=0.89. Substitution of placebo for the active drug caused prompt reappearance of symptoms of cardiac overactivity in each patient, and brought the circulatory functions back to these levels: SAP=157; HR=96; Cl=5530; MSEJR=245; delta P/delta t=1.33. These findings lend further credence to the concept that the PHHS is, indeed, a definable disease entity; they also document that propranolol ameliorates the symptoms of the disease but is ineffective for the underlying disorder.
12名患有原发性运动亢进性心脏病综合征（PHHS）的男性表现出心悸、心跳快速且有力、大动脉搏动增强、心脏收缩期杂音以及以下循环系统数值（平均值）：收缩压（SAP）=154毫米汞柱；心率（HR）=91次/分钟；心脏指数（Ci）=5494毫升/分钟/平方米；左心室平均收缩期射血速率指数（SMEJR）=227毫升/分钟/平方米；左心室平均射血前期ΔP/Δt（ΔP/Δt）=1.32毫米汞柱/毫秒。在为期两年的随访期间，给予普萘洛尔（80 - 160毫克/天），结果显示主观症状有明显改善，循环运动亢进的体征消失。在此期间结束时，血液动力学功能如下：SAP = 134；HR = 69；Cl = 3489；MSEJR = 171；ΔP/Δt = 0.89。用安慰剂替代活性药物后，每位患者心脏活动过度的症状迅速再次出现，循环功能恢复到以下水平：SAP = 157；HR = 96；Cl = 5530；MSEJR = 245；ΔP/Δt = 1.33。这些发现进一步证实了PHHS确实是一种可定义的疾病实体这一概念；它们还证明普萘洛尔可改善该疾病的症状，但对潜在病症无效。
