Sheline Yvette I, Gado Mokhtar H, Kraemer Helena C
Department of Psychiatry, Mallinckrodt Institute of Tadiology, Washington Univeristsy School of Medicine, St Louis, MO 63110, USA.
Am J Psychiatry. 2003 Aug;160(8):1516-8. doi: 10.1176/appi.ajp.160.8.1516.
The purpose of this study was to investigate the effect of antidepressant treatment on hippocampal volumes in patients with major depression.
For 38 female outpatients, the total time each had been in a depressive episode was divided into days during which the patient was receiving antidepressant medication and days during which no antidepressant treatment was received. Hippocampal gray matter volumes were determined by high resolution magnetic resonance imaging and unbiased stereological measurement.
Longer durations during which depressive episodes went untreated with antidepressant medication were associated with reductions in hippocampal volume. There was no significant relationship between hippocampal volume loss and time depressed while taking antidepressant medication or with lifetime exposure to antidepressants.
Antidepressants may have a neuroprotective effect during depression.
本研究旨在调查抗抑郁治疗对重度抑郁症患者海马体积的影响。
对于38名女性门诊患者，将她们处于抑郁发作的总时间分为接受抗抑郁药物治疗的天数和未接受抗抑郁治疗的天数。通过高分辨率磁共振成像和无偏立体测量法测定海马灰质体积。
抑郁发作未接受抗抑郁药物治疗的时间越长，海马体积减小越明显。海马体积损失与服用抗抑郁药物时的抑郁时间或终生接触抗抑郁药物之间无显著关系。
抗抑郁药在抑郁症期间可能具有神经保护作用。
