Pueschel S M, Rothman K J, Ogilby J D
Am J Ment Defic. 1976 Jan;80(4):442-5.
The difference in birth weight between children with Down's syndrome and their siblings was estimated to be in the interval from .18 to .37 kg with 90 percent confidence, the Down's syndrome infants having the smaller mean birth weights. When we adjusted their birth weight, using a multiple linear regression analysis, to take into account several factors known to affect it, the difference in birth weight was only slightly less than the unadjusted difference. The data support the hypothesis that an extra chromosome No. 21 results in a smaller than expected birth weight.
据估计，唐氏综合征患儿与其兄弟姐妹的出生体重差异在0.18至0.37千克之间，置信度为90%，唐氏综合征婴儿的平均出生体重较小。当我们使用多元线性回归分析调整他们的出生体重，以考虑几个已知会影响出生体重的因素时，出生体重差异仅略小于未调整的差异。这些数据支持这样一种假设，即额外的21号染色体会导致出生体重低于预期。
