[内皮细胞激活和血管生成中的钙离子/钙调神经磷酸酶/活化T细胞核因子信号传导：环孢素A的作用] - Suppr

[CA++/ calcineurin/NFAT signaling in endothelial activation and angiogenesis: effects od cyclosporin A ].

作者信息

Quesada A J, Redondo J M

机构信息

Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid y Centro Nacional de Investigaciones Cardiovasculares (CNIC), Sinesio Delgado, 4 28049 Cantoblanco, Madrid.

出版信息

Nefrologia. 2003;23 Suppl 3:44-8.

PMID:12901192

Abstract

摘要

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[CA++/ calcineurin/NFAT signaling in endothelial activation and angiogenesis: effects od cyclosporin A ].[内皮细胞激活和血管生成中的钙离子/钙调神经磷酸酶/活化T细胞核因子信号传导：环孢素A的作用]

Nefrologia. 2003;23 Suppl 3:44-8.

[Immunosuppressive drugs and calcineurin].[免疫抑制药物与钙调神经磷酸酶]

Tanpakushitsu Kakusan Koso. 1998 Sep;43(12 Suppl):1739-43.

[A second target of cyclosporin A and FK506].[环孢素A和FK506的第二个靶点]

Tanpakushitsu Kakusan Koso. 2000 Aug;45(11):1823-31.

Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression.通过化学遗传学鉴定NFAT抑制剂：在免疫抑制中靶向钙动员的潜力

Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8969-74. doi: 10.1073/pnas.0402803101. Epub 2004 Jun 7.

VEGF selectively induces Down syndrome critical region 1 gene expression in endothelial cells: a mechanism for feedback regulation of angiogenesis?血管内皮生长因子在内皮细胞中选择性诱导唐氏综合征关键区域1基因表达：一种血管生成反馈调节机制？

Biochem Biophys Res Commun. 2004 Aug 27;321(3):648-56. doi: 10.1016/j.bbrc.2004.06.176.

[Multiple actions of tacrolimus and cyclosporin A as specific inhibitors of calcineurin].[他克莫司和环孢素A作为钙调神经磷酸酶特异性抑制剂的多种作用]

Tanpakushitsu Kakusan Koso. 1998 Jun;43(8 Suppl):1118-30.

Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth.钙调神经磷酸酶-NFAT与MEK1-细胞外信号调节激酶1/2信号通路之间的直接和间接相互作用调节心脏基因表达和细胞生长。

Mol Cell Biol. 2005 Feb;25(3):865-78. doi: 10.1128/MCB.25.3.865-878.2005.

Activation of the Ca(2+)/calcineurin/NFAT2 pathway controls smooth muscle cell differentiation.Ca(2+)/钙调神经磷酸酶/NFAT2信号通路的激活控制平滑肌细胞分化。

Exp Cell Res. 2005 Oct 15;310(1):166-75. doi: 10.1016/j.yexcr.2005.07.021.

Cyclosporin A promotes growth and invasiveness in vitro of human first-trimester trophoblast cells via MAPK3/MAPK1-mediated AP1 and Ca2+/calcineurin/NFAT signaling pathways.环孢素A通过MAPK3/MAPK1介导的AP1和Ca2+/钙调神经磷酸酶/NFAT信号通路促进人早孕滋养层细胞的体外生长和侵袭。

Biol Reprod. 2008 Jun;78(6):1102-10. doi: 10.1095/biolreprod.107.063503. Epub 2008 Mar 5.

Interference of antihypertrophic molecules and signaling pathways with the Ca2+-calcineurin-NFAT cascade in cardiac myocytes.抗肥厚分子和信号通路对心肌细胞中Ca2+-钙调神经磷酸酶-NFAT级联反应的干扰。

Cardiovasc Res. 2004 Aug 15;63(3):450-7. doi: 10.1016/j.cardiores.2004.04.002.

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Anti-inflammatory effects of water extract from bell pepper (. var. ) leaves .甜椒（.变种.）叶水提取物的抗炎作用

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Immunosuppressive activity of daphnetin, one of coumarin derivatives, is mediated through suppression of NF-κB and NFAT signaling pathways in mouse T cells.香豆素衍生物瑞香素的免疫抑制活性是通过抑制小鼠 T 细胞中的 NF-κB 和 NFAT 信号通路来介导的。

PLoS One. 2014 May 6;9(5):e96502. doi: 10.1371/journal.pone.0096502. eCollection 2014.

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[CA++/ calcineurin/NFAT signaling in endothelial activation and angiogenesis: effects od cyclosporin A ].

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