急性缺氧时血浆和组织中一氧化碳的变化
Change of carbon monoxide in plasma and tissue during acute hypoxia.
作者信息
Ding Xueqin, Liu Guiming, Wang Junke, Sheng Zhuoren
机构信息
Department of Anesthesiology and ICU, the First Affiliated Hospital, China Medical University, Shenyang 110001.
出版信息
Chin Med Sci J. 2003 Mar;18(1):50-3.
OBJECTIVE
To investigate the role of endogenous carbon monoxide (CO) in hypoxia.
METHODS
After rats were inhaled with hypoxic gases and the heme oxygenase inhibitor ZnPPIX was administered, we measured the CO levels in plasma, liver, lung and kidney. Meanwhile plasma cGMP levels were observed. Furthermore, we recorded the change of hemodynamic and blood gases.
RESULTS
Acute mild hypoxia (10% O2) significantly increaed CO levels in plasma as well as liver, kidney and lung, while acute severe hypoxia (5% O2) significantly decreased CO levels in plasma as well as liver, kidney and lung. In addition, the former significantly elevated cGMP levels in plasma while the latter markedly reduced cGMP levels in plasma. The hemodynamic change occurred in accordance with the changes carbon monoxide.
CONCLUSION
Our results indicate, for the first time, that the endogenous carbon monoxide plays an important role in regulating the vessel tone during hypoxia.
目的
研究内源性一氧化碳（CO）在缺氧中的作用。
方法
大鼠吸入低氧气体并给予血红素加氧酶抑制剂ZnPPIX后，我们测量了血浆、肝脏、肺和肾脏中的CO水平。同时观察血浆cGMP水平。此外，我们记录了血流动力学和血气的变化。
结果
急性轻度缺氧（10% O₂）显著增加血浆以及肝脏、肾脏和肺中的CO水平，而急性重度缺氧（5% O₂）显著降低血浆以及肝脏、肾脏和肺中的CO水平。此外，前者显著升高血浆中的cGMP水平，而后者显著降低血浆中的cGMP水平。血流动力学变化与一氧化碳的变化一致。
结论
我们的结果首次表明，内源性一氧化碳在缺氧期间调节血管张力中起重要作用。
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