Claerebout Edwin, Knox David P, Vercruysse Jozef
Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Expert Rev Vaccines. 2003 Feb;2(1):147-57. doi: 10.1586/14760584.2.1.147.
Vaccination is being considered as the most feasible alternative for anthelmintic drugs to control gastrointestinal nematode infections in cattle. However, despite the identification of several candidate protective antigens, no vaccines against gastrointestinal nematode parasites are currently available. The main problems that hamper the development of nematode vaccines in ruminants are that vaccination with recombinant nematode proteins produced in bacterial or eukaryotic expression systems did not induce a protective immune response and no suitable antigen delivery system is available for presentation of protective worm antigens to the bovine mucosal immune system. The present review will focus on recent advances and remaining obstacles in vaccine development against gastrointestinal nematodes in cattle, in particular against the abomasal parasite Ostertagia ostertagi.
接种疫苗被认为是替代驱虫药来控制牛胃肠道线虫感染的最可行办法。然而，尽管已鉴定出几种候选保护性抗原，但目前尚无针对胃肠道线虫寄生虫的疫苗。阻碍反刍动物线虫疫苗开发的主要问题是，用细菌或真核表达系统生产的重组线虫蛋白进行接种不能诱导产生保护性免疫反应，而且没有合适的抗原递送系统可用于将保护性蠕虫抗原呈递给牛的黏膜免疫系统。本综述将聚焦于牛胃肠道线虫疫苗开发的最新进展和尚存的障碍，特别是针对皱胃寄生虫奥斯特他线虫（Ostertagia ostertagi）的疫苗开发情况。
