Bindal Aditya, Narsimhan Ganesan, Hem Stanley L, Kulshreshtha Alok
Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, Indiana 47907, USA.
Pharm Dev Technol. 2003 Aug;8(3):219-28. doi: 10.1081/pdt-120022151.
The effect of steam sterilization (dwell@121 degrees C) on the apparent viscosity of solutions of carbomer 940P, guar gum, hydroxyethylcellulose (HEC), and xanthan gum was studied. Guar gum and carbomer 940P could be steam sterilized for 30 min without any change in the apparent viscosity. Steam sterilization of HEC and xanthan gum resulted in a substantial decrease in the apparent viscosity and the desirable shear-thinning rheology. The addition of sodium chloride to either polymer prior to steam sterilization diminished the effect of sterilization on the rheology. The apparent viscosity of xanthan solutions was not significantly affected if the solution was made isotonic with sodium chloride (0.15 M). The addition of sodium chloride to xanthan gum after steam sterilization resulted in full recovery of the initial rheological properties. Carbomers, guar gum, and xanthan (in 0.15 M NaCI) are candidates for use in pharmaceutical solutions/suspensions that are subjected to steam sterilization.
研究了蒸汽灭菌（在121摄氏度下保温）对卡波姆940P、瓜尔胶、羟乙基纤维素（HEC）和黄原胶溶液表观粘度的影响。瓜尔胶和卡波姆940P可以进行30分钟的蒸汽灭菌，表观粘度无任何变化。对HEC和黄原胶进行蒸汽灭菌会导致表观粘度大幅降低以及理想的剪切变稀流变学特性丧失。在蒸汽灭菌前向任何一种聚合物中添加氯化钠可减轻灭菌对流变学的影响。如果黄原胶溶液用氯化钠（0.15M）制成等渗溶液，其表观粘度不会受到显著影响。蒸汽灭菌后向黄原胶中添加氯化钠可使初始流变学特性完全恢复。卡波姆、瓜尔胶和黄原胶（在0.15M氯化钠中）可用于经受蒸汽灭菌的药物溶液/混悬液。
