Finton Michael J, Lucas John A, Rippeth Julie D, Bohac Daryl L, Smith Glenn E, Ivnik Robert J, Petersen Ronald C, Graff-Radford Neill R
The Wallace-Kettering Neuroscience Institute, Kettering, Ohio, USA.
J Int Neuropsychol Soc. 2003 Jul;9(5):751-9. doi: 10.1017/S1355617703950089.
The relationship between apolipoprotein E (apoE) genotype and cognitive performance was examined in 200 patients with probable Alzheimer's disease (AD). Differences between composite measures of verbal and nonverbal functioning were used to define asymmetric patterns of cognition. Patients who were homozygous for apoE epsilon4 demonstrated relatively worse nonverbal as compared to verbal cognitive ability. In contrast, participants who were heterozygous for apoE epsilon4 or who possessed no epsilon4 allele demonstrated relatively equivalent verbal and nonverbal cognitive abilities. Although age and dementia severity also contributed to these patterns, apoE genotype appears to have a significant unique contribution to cognitive performance in these individuals. The epsilon4 allele may thus be associated with a specific neurocognitive phenotype among patients with AD, with the overall pattern of cognitive asymmetry dependent upon epsilon4 dose.
在200例可能患有阿尔茨海默病（AD）的患者中，研究了载脂蛋白E（apoE）基因型与认知表现之间的关系。使用语言和非语言功能的综合测量差异来定义认知的不对称模式。apoE ε4纯合子患者的非语言认知能力相对较差，而语言认知能力相对较好。相比之下，apoE ε4杂合子或没有ε4等位基因的参与者的语言和非语言认知能力相对相当。虽然年龄和痴呆严重程度也促成了这些模式，但apoE基因型似乎对这些个体的认知表现有显著的独特贡献。因此，ε4等位基因可能与AD患者的特定神经认知表型相关，认知不对称的总体模式取决于ε4剂量。
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