Ege Turan, Canbaz Suat, Yuksel Volkan, Duran Enver
Department of Cardiovascular Surgery, Medical Faculty, Trakya University, TR 22030 Edirne, Turkey.
Cytokine. 2003 Jul;23(1-2):47-51. doi: 10.1016/s1043-4666(03)00180-7.
We investigated the effects of pro-inflammatory cytokines of pericardial fluid on hemodynamic parameters in patients undergoing coronary artery surgery. Seventy-eight patients were included in the study and they were allocated to three groups: group 1, stable angina pectoris (SAP, n = 15); group 2, unstable angina pectoris (USAP, n = 34); group 3, post-myocardial infarction (PMI, n = 29). Pericardial fluid and arterial blood samples were obtained from all patients and interleukin (IL)-1beta, IL-2 receptor, IL-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha) levels were measured. Pericardial IL-1beta concentration (pg/mL) was significantly higher in the USAP group (26.6 +/- 10.9) compared to the SAP (5.0 +/- 0.1) and PMI (5.8 +/- 1.0) groups. IL-2R, IL-6, IL-8 and TNF-alpha concentrations of pericardial fluid were significantly higher than serum in all groups; difference was more prominent in the PMI group compared to the SAP and the USAP groups. Serum IL-1beta concentrations (pg/mL) were significantly higher in the USAP group (21.8 +/- 3.4) compared to the SAP group (5.0 +/- 0.1) and the PMI group (5.4 +/- 1.6). Cardiac index (CI) before opening the pericardial sac was found to be lower in the USAP group (1.6 +/- 0.3 L/min/m2) compared to the SAP (2.2 +/- 0.5 L/min/m2) and the PMI (2.1 +/- 0.5 L/min/m2) groups (p = 0.028 and p = 0.011, respectively). In the USAP group, there was a relationship between reduction of CI and increase of IL-1beta levels in serum and pericardial fluid.
我们研究了心包液中促炎细胞因子对接受冠状动脉手术患者血流动力学参数的影响。78例患者纳入本研究，被分为三组：1组，稳定型心绞痛（SAP，n = 15）；2组，不稳定型心绞痛（USAP，n = 34）；3组，心肌梗死后（PMI，n = 29）。采集所有患者的心包液和动脉血样本，检测白细胞介素（IL）-1β、IL-2受体、IL-6、IL-8和肿瘤坏死因子-α（TNF-α）水平。与SAP组（5.0±0.1）和PMI组（5.8±1.0）相比，USAP组心包IL-1β浓度（pg/mL）显著更高（26.6±10.9）。所有组心包液中IL-2R、IL-6、IL-8和TNF-α浓度均显著高于血清；与SAP组和USAP组相比，PMI组差异更显著。与SAP组（5.0±0.1）和PMI组（5.4±1.6）相比，USAP组血清IL-1β浓度（pg/mL）显著更高（21.8±3.4）。发现与SAP组（2.2±0.5 L/min/m²）和PMI组（2.1±0.5 L/min/m²）相比，USAP组心包囊打开前的心指数（CI）更低（1.6±0.3 L/min/m²）（分别为p = 0.028和p = 0.011）。在USAP组，血清和心包液中CI降低与IL-1β水平升高之间存在关联。
