Ege Turan, Us Melih Hulusi, Cikirikcioglu Mustafa, Arar Cavidan, Duran Enver
Department of Cardiovascular Surgery, Trakya University Medical Faculty, Edirne, Turkey.
Yonsei Med J. 2006 Jun 30;47(3):372-6. doi: 10.3349/ymj.2006.47.3.372.
This study was designed to examine the relationship between pericardial fluid and plasma CRP levels, and to alterations in other biochemical parameters in patients undergoing Coronary Artery Bypass Grafting (CABG). The study group consisted of 96 Coronary Artery Disease (CAD) patients who were referred to our clinic for a CABG procedure and from whom sufficient amount of pericardial fluid could be collected. The patients were classified into 3 groups: Stable Angina Pectoris (SAP) (n=27), Unstable Angina Pectoris (USAP) (n=36), and Post-Myocardial Infarction (PMI) (n=33). Levels of CRP, glucose, albumin, total protein, Creatine Kinase (CK), Creatine Kinase-MB (CK-MB), and Lactate Dehydrogenase (LDH) were determined in pericardial fluid samples and in simultaneously collected blood samples from radial artery. The pericardial CRP and LDH levels in the PMI group were higher than in the SAP (p=0.015 and p=0.000, respectively) and USAP (p=0.011, p=0.047) groups. Serum CRP levels in USAP (p=0.014) and PMI (p= 0.000) groups were higher than those in the SAP group. Pericardial albumin levels in the PMI group were higher than in the USAP group (p=0.038). In all groups, the pericardial fluid/serum protein ratio was > 0.5, the LDL ratio was > 0.6, and pericardial fluid LDH concentrations were > 300 mg/dl. CRP level of pericardial fluid was significantly higher in the PMI group than in other groups. However, pericardial fluid LDH levels were higher than blood LDH levels in this group and were also higher than pericardial fluid LDH levels of other groups.
本研究旨在探讨冠状动脉旁路移植术（CABG）患者心包积液与血浆CRP水平之间的关系，以及其他生化参数的变化。研究组由96例因CABG手术转诊至我院且能收集到足够量心包积液的冠状动脉疾病（CAD）患者组成。患者分为3组：稳定型心绞痛（SAP）组（n = 27）、不稳定型心绞痛（USAP）组（n = 36）和心肌梗死后（PMI）组（n = 33）。测定心包积液样本以及同时从桡动脉采集的血样中CRP、葡萄糖、白蛋白、总蛋白、肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）和乳酸脱氢酶（LDH）的水平。PMI组的心包CRP和LDH水平高于SAP组（分别为p = 0.015和p = 0.000）和USAP组（p = 0.011，p = 0.047）。USAP组（p = 0.014）和PMI组（p = 0.000）的血清CRP水平高于SAP组。PMI组的心包白蛋白水平高于USAP组（p = 0.038）。在所有组中，心包积液/血清蛋白比值> 0.5，LDL比值> 0.6，心包积液LDH浓度> 300 mg/dl。PMI组心包积液的CRP水平显著高于其他组。然而，该组心包积液LDH水平高于血LDH水平，也高于其他组的心包积液LDH水平。
