Juraschko K, Meyer-Lindenberg A, Nolte I, Distl O
Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Bünteweg 17p, 30559, Hannover, Germany.
Vet J. 2003 Sep;166(2):164-9. doi: 10.1016/s1090-0233(02)00256-3.
We have analysed the systematic influences, phenotypic colour markers and the additive genetic variation for congenital sensorineural deafness (CSD) in German Dalmatian dogs in order to help elucidate the importance of phenotypic breed characteristics for genetic differences of CSD. Linear animal models using restricted maximum likelihood methods were employed to estimate variance components. Data were obtained from all three German Dalmatian kennel clubs associated with the German Association for Dog Breeding and Husbandry (VDH). CSD was recorded by standardized protocols for brainstem auditory-evoked response (BAER). The material included 1899 German Dalmatian dogs from 354 litters in 169 different kennels. BAER testing results were from the years 1986 to 1999. Pedigree information was available for up to seven generations. The animal model regarded the fixed effects of sex, coat colour, eye colour, presence of patches, litter size, percentage of examined puppies per litter, kennel club, and inbreeding coefficient. The common environment of the litter and kennel as well as the additive genetic effect of the animal were taken into account as randomly distributed effects. The fixed effects of eye colour, percentage of puppies examined per litter and kennel club were significant in the mixed model analysis. A significant proportion of additive genetic variation could be shown despite corrections for phenotypic colour variants. The heritability estimate for CSD in German Dalmatian dogs was h(2)=0.27+/-0.07. The additive genetic correlation of CSD with presence of blue eyes was r(g)=0.53+/-0.41 and with presence of patches r(g)=-0.36+/-0.24. We concluded that additional genes other than those associated with phenotypic colour markers in German Dalmatian dogs significantly contribute to the occurrence of CSD.
我们分析了德国达尔马提亚犬先天性感音神经性耳聋（CSD）的系统影响、表型颜色标记和加性遗传变异，以帮助阐明表型品种特征对CSD遗传差异的重要性。采用限制最大似然法的线性动物模型来估计方差成分。数据来自与德国犬类育种与饲养协会（VDH）相关的所有三个德国达尔马提亚犬舍俱乐部。通过标准化的脑干听觉诱发电位（BAER）方案记录CSD。材料包括来自169个不同犬舍的354窝的1899只德国达尔马提亚犬。BAER测试结果来自1986年至1999年。谱系信息可追溯到多达七代。动物模型考虑了性别、被毛颜色、眼睛颜色、斑块的存在、窝仔数、每窝检查幼犬的百分比、犬舍俱乐部和近亲繁殖系数的固定效应。窝和犬舍的共同环境以及动物的加性遗传效应被视为随机分布效应。在混合模型分析中，眼睛颜色、每窝检查幼犬的百分比和犬舍俱乐部的固定效应是显著的。尽管对表型颜色变异进行了校正，但仍可显示出相当比例的加性遗传变异。德国达尔马提亚犬CSD的遗传力估计值为h(2)=0.27±0.07。CSD与蓝眼存在的加性遗传相关性为r(g)=0.53±0.41，与斑块存在的加性遗传相关性为r(g)=-0.36±0.24。我们得出结论，德国达尔马提亚犬中除了与表型颜色标记相关的基因外，其他基因也对CSD的发生有显著贡献。
